Seizure control in antiepileptic drug-treated pregnancy

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Antiepileptic drug clearance and seizure frequency during pregnancy in women with epilepsy.

The aims of the study were to characterize the magnitude of clearance changes during pregnancy for multiple antiepileptic drugs (AEDs) and to assess seizure frequency and factors increasing seizure risk in pregnant women with epilepsy. A retrospective analysis was performed for 115 pregnancies in 95 women with epilepsy followed at the Emory Epilepsy Center between 1999 and 2012. Antiepileptic d...

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Seizure in Patients with Antiepileptic Drug Overdose: Study on Patients Admitted To Shoushtari Hospital in Shiraz

Background: Poisoning with non-barbiturate anti-epileptics (carbamazepine, sodium valproate and phenytoin) shows a growing trend. The objective of this study was to investigate clinical manifestations of poisoned patients with these medications. Methods: This prospective study was conducted in the Shiraz Shoushtari Hospital during a two-year period from 2010 to 2012. Poisoning was confirmed acc...

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Random total antiepilectic drug levels and seizure control during pregnancy.

OBJECTIVE To study the correlation of randomly-tested total antiepileptic plasma levels and seizure control in a retrospectively collected group of pregnant epileptic Saudi women. METHODS The medical records of 30 Saudi epileptic female patients were reviewed during their subsequent pregnancies (total of 50). The type of antiepileptic drugs used during each pregnancy, the dose of each drug an...

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North American antiepileptic drug pregnancy registry.

Background: The North American AED (antiepileptic drug) Pregnancy Registry was established in 1997 for pregnant women in the United States and Canada at the Massachusetts General Hospital in Boston, Massachusetts. The major objective was to obtain, as quickly as possible, information on the frequency of major malformations among infants whose mothers had taken one or more AEDs to prevent seizur...

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Antiepileptic drug use during pregnancy: Perinatal outcomes

PURPOSE This study was undertaken to (1) measure the frequency of AED monotherapy or polytherapy during pregnancy and AED discontinuation prior to pregnancy in a cohort of women with treated epilepsy; and (2) describe the frequency of major congenital malformations according to maternal use of AED during pregnancy. METHODS A cohort of epileptic pregnant women was identified within the Quebec ...

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ژورنال

عنوان ژورنال: Epilepsia

سال: 2008

ISSN: 0013-9580,1528-1167

DOI: 10.1111/j.1528-1167.2007.01412.x